Clinical Research and Our Journey

Since 2014, NFANT Labs has been dedicated to supporting clinical improvements through objective data and predictive analytics with the first FDA cleared IoT device and machine learning platform for the Neonatal ICU.

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April 12, 2018

December 11, 2017

Caregiver Education to Advance the Development of Feeding Skill in Fragile Infants

This poster, presented by Dr. Gilson Capilouto, demonstrates the benefits of combining real time objective feedback and expert guidance on caregiver training.

Machine Learning Techniques Indicate Relative Risk For Underlying Post Discharge Feeding Issues

Findings suggest that otherwise healthy preterm infants may have underlying feeding issues at discharge that go undetected using traditional NICU assessment focused mainly on age and weight.

June 8, 2017

NFANT Labs' poster presentation on nfant Feeding Solution and nfant's machine learning analytics

Preliminary Investigation of Machine Learning on Neonatal ICU Feeding Transition

November 7, 2018

Establishing The Evidence: Using objective metrics to support the transition to oral feeding

Presented by Dr. Capilouto and Dr. Cunningham.

 Through the use of case studies, graphics, and video this course provides the basic understanding needed to integrate real-time biofeedback and objective metrics into your current feeding practice.

September 12, 2016

Feeding Difficulties of Late and Moderate Preterm Infants

The first in a series of papers which describes an example clinical protocol for nfant®Feeding Solution implementation. The protocol was developed by our Chief Clinical Officer, Dr. Gilson Capilouto and is based on her own implementation of the device.

Objective Assessment of a Preterm Infant’s Nutritive Sucking

This case study illustrates the clinical utility of nfant® Feeding Solution as a noninvasive and objective instrument for determining a neonate’s readiness to begin and advance oral feeding.

January 2016

May 26, 2014

February 7, 2017

Exploring the Link Between Neonatal Brain Injury and Sucking

A whitepaper outlining the clinical partnership with NFANT Labs and researchers at Harvard Medical School & Boston Children’s Hospital to investigate neonatal sucking patterns as an indicator of neurodevelopment. This research program will provide clear evidence of the association between early abnormalities in feeding performance and underlying brain injury.

March 2017

Quantifying Neonatal Sucking Performance: Promise of New Methods

A study published in Thieme’s Seminars in Speech and Language indicates that an infant’s ability to feed, or sucking performance, may correlate with neurodevelopmental outcomes. This highlights the need to include neonatal sucking assessment as part of routine clinical care in order to capture the relative risk of adverse neurodevelopmental outcomes at discharge. 

July 11, 2019

A comparison of the nutritive sucking performance of full term and preterm neonates at hospital discharge: A prospective study

A peer-reviewed study featuring nfant® Feeding Solution published in Early Human Development showing objective feeding metrics produced by nfant® Analytics predicted the feeding-related length of stay of preterm and full-term infants.  The study concludes that these results support the need to screen infant feeding ability prior to discharge home to identify those at-risk for feeding problems, initiate early intervention sooner, and reduce hospital readmission rates. These findings reflect the emerging consensus that objective assessment of feeding ability during a hospital stay may help identify infants at risk for delay in discharge or readmission.

October 25, 2019

nfant® Feeding Solution adds evidence to optimize feeding interventions

A recent peer-reviewed study published in the Journal of Perinatal and Neonatal Nursing demonstrates how visual feedback combined with objective sucking performance metrics can be used to compare sucking skill pre/post intervention and facilitate evidence-based decisions that optimize and personalize feeding.

Febuary 1, 2019

Study Shows nfant® Nipples are Best in Class

Recent research demonstrates that nfant® Nipples are the slowest and most reliable flow rates on the market today.


Consistent and safe flow rates play an important role in any infant's successful transition to full oral feeding.  This is particularly important in infants with complex medical conditions.  nfant® Nipples deliver on these goals and represent NFANT Labs' continued commitment to providing research-based tools to promote safe and healthy feedings.

September 1, 2019

Oral Feeding #1 Barrier to Hospital Discharge 

- Journal of Perinatology

A study funded by the NICHD found that inadequate oral feeding is the most common barrier to hospital discharge for moderately preterm infants (MPT), even after accounting for neonatal morbidities. The study involved over 6,000 MPT infants (born 29 to 33 weeks) across 18 facilities nationwide.

Results showed that 39% of all MPT infants remained hospitalized at 36 weeks of age due to a feeding-related issue. Prolonged hospitalization has been shown to correlate with failure to thrive and coping with feeding issues is a primary concern for families both in the hospital and once they go home. Researchers concluded that a standardized protocol for determining the introduction and progression of oral feeding is needed to reduce the length of stay for MPT infants while simultaneously addressing large variations in practice that exist across facilities.

November 22, 2019

nfant® Metrics correlate with neonatal brain injury  

- Journal of Perinatology

A clinical study led by researchers at Boston Children’s Hospital and Harvard Medical School found that nutritive sucking metrics captured via nfant® Feeding Solution correlated with neonatal brain injury. The findings supported the researchers’ hypothesis that structural integrity of the sensorimotor brain network is reflected in the infant’s nutritive sucking, which represents a potential early indicator of white-matter brain injury in newborns hospitalized in the NICU. Early identification of underlying brain injury allows patients to benefit from early intervention services as soon as possible.

Development Comparison of Tongue Muscle Characteristics of Preterm and Full Term Infants during Nutritive and Nonnutritive Sucking

Independent oral feeding requires coordination of suck, swallow, and breathe, and the lingual musculature plays a significant role in this coordinative action. This paper explores clinical benchmarks in fundamental lingual function as it relates to feeding success.

Why We Do It